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Related Concept Videos

Selectins01:25

Selectins

3.9K
Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...
3.9K
Activation of Integrins01:15

Activation of Integrins

4.7K
Integrins bind ligands and transmit information from outside the cell to inside or vice-versa through an "outside-in signaling" or "inside-out signaling."
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding...
4.7K
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

3.0K
Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
3.0K
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

8.6K
Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved...
8.6K
Integrins01:10

Integrins

4.9K
Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...
4.9K
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

3.3K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
3.3K

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Related Experiment Video

Updated: Dec 12, 2025

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
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Selectins in cancer immunity.

Lubor Borsig1

  • 1Institute of Physiology, University of Zurich and Zurich Center for Integrative Human Physiology, Winterthurerstrasse 190, Zurich, Switzerland.

Glycobiology
|December 23, 2017
PubMed
Summary

Selectins, crucial for immune responses, also drive cancer metastasis by mediating tumor cell interactions. Targeting selectin-mediated immune modulation offers a novel strategy for cancer therapy.

Area of Science:

  • Cellular and Molecular Biology
  • Immunology
  • Oncology

Background:

  • Selectins are vascular adhesion molecules involved in inflammation, immunity, and hemostasis.
  • In cancer, selectins facilitate tumor cell interactions with platelets, endothelial cells, and leukocytes, promoting metastasis.
  • Selectins bind to specific sialylated, fucosylated glycan structures, with increased ligand expression correlating to poor prognosis.

Purpose of the Study:

  • To review the role of selectins in immune modulation during cancer progression.
  • To explore selectin-mediated signaling cascades that regulate the tumor immune microenvironment.
  • To identify selectin-induced immune modulation as a potential therapeutic target in cancer.

Main Methods:

  • Literature review of studies on selectin function in cancer metastasis and immunity.

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Experimental Metastasis and CTL Adoptive Transfer Immunotherapy Mouse Model
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Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
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In vitro Method to Observe E-selectin-mediated Interactions Between Prostate Circulating Tumor Cells Derived From Patients and Human Endothelial Cells
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  • Analysis of selectin-ligand interactions and their impact on cellular signaling.
  • Synthesis of evidence regarding selectin-mediated immune responses within the tumor microenvironment.

    • Main Results:

    • Selectins mediate tumor cell adhesion and extravasation, contributing to metastasis.
    • Selectin binding, particularly L-selectin, activates leukocytes.
    • Interactions involving PSGL-1, P-selectin, and E-selectin trigger intracellular signaling pathways.

    Conclusions:

    • Selectins play a dual role in cancer, promoting metastasis and modulating immune responses.
    • Selectin-mediated immune modulation within the tumor microenvironment is a critical aspect of cancer progression.
    • Targeting selectin-induced immune modulation presents a promising avenue for developing novel cancer immunotherapies.