The Next Step Forward in Ubiquitin-Specific Protease 7 Selective Inhibition
Matthieu Desroses1, Mikael Altun1
1Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Molecular Biochemistry and Biophysics, Karolinska Institutet, Stockholm 171 65, Sweden.
Cell Chemical Biology
|December 23, 2017
Abstract:
Ubiquitin-specific protease 7 is a validated anticancer target; thus, selective USP7 inhibitors are of great interest. In this issue of Cell Chemical Biology, Lamberto et al. (2017) and Pozhidaeva et al. (2017) report important insights into the structural inhibitor-enzyme interplay, lighting the way toward the development of selective inhibitors.
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