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Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

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The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
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Related Experiment Video

Updated: Feb 16, 2026

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
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Multifunctional YY1 in Liver Diseases.

Mengjie Zhang1,2, Yi Zhang3, Shuang Yang4

  • 1Department of Pathophysiology, Third Military Medical University, Chongqing, People's Republic of China.

Seminars in Liver Disease
|December 23, 2017
PubMed
Summary

The transcription factor Yin Yang 1 (YY1) plays a key role in liver diseases by affecting gene expression and cellular metabolism. Targeting YY1 offers potential for novel liver disease therapies.

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Last Updated: Feb 16, 2026

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
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Area of Science:

  • Molecular Biology
  • Hepatology
  • Cellular Metabolism

Background:

  • Yin Yang 1 (YY1) is a conserved, multifunctional transcription factor regulating gene expression across diverse cell types.
  • YY1's roles in proliferation, differentiation, and apoptosis are context-dependent.
  • Aberrant YY1 expression is linked to liver pathologies, including hepatocellular carcinoma and viral hepatitis.

Purpose of the Study:

  • To review current knowledge on YY1's involvement in liver diseases.
  • To discuss YY1's molecular pathogenic mechanisms in liver conditions.
  • To evaluate YY1 as a potential therapeutic target for liver disease.

Main Methods:

  • Literature review of recent studies on YY1 in liver disease.
  • Analysis of YY1's role in cellular metabolism (glycometabolism, lipid, bile acid).
  • Discussion of molecular mechanisms underlying YY1-mediated liver pathology.

Main Results:

  • YY1 is implicated in liver fibrosis, carcinogenesis, and viral-induced injury.
  • YY1 significantly influences dysregulated glycometabolism, lipid metabolism, and bile acid metabolism in disease.
  • Emerging evidence highlights YY1's deep involvement in metabolic dysregulation in liver diseases.

Conclusions:

  • YY1 is a critical factor in the pathogenesis of various liver diseases.
  • Understanding YY1's mechanisms provides insights into disease progression.
  • YY1 represents a promising target for developing new liver disease therapies.