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On how role versatility boosts an STI.

Andrés J Cortés1

  • 1Department of Biological and Environmental Sciences, University of Gothenburg, Carl Skottsbergs gata 22B, Gothenburg 41319, Sweden; Colombian Corporation for Agricultural Research (Corpoica), C.I. La Selva, Km 7 Vía Rionegro - Llanogrande, Rionegro, Colombia.

Journal of Theoretical Biology
|December 24, 2017
PubMed
Summary
This summary is machine-generated.

Role versatility in men who have sex with men (MSM) increases HIV-1 prevalence, even with bidirectional transmission. This finding challenges previous assumptions about unprotected anal intercourse (UAI) risks in this population.

Keywords:
Bidirectional virus transmissionHIV-1Men who have sex with men (MSM)Role segregationSexual rolesSexually transmitted infections (STIs)

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Area of Science:

  • Epidemiology
  • Mathematical Modeling
  • Public Health

Background:

  • HIV-1 prevalence remains high among men who have sex with men (MSM) despite control efforts.
  • Unprotected anal intercourse (UAI) and sexually transmitted infections (STIs) are persistent challenges in MSM communities.
  • MSM populations exhibit diverse sexual role practices, including fixed (insertive/receptive) and versatile (both) roles.

Discussion:

  • Older models predicted higher HIV-1 transmission with role versatility, assuming negligible risk from insertive anal intercourse (UIA).
  • Newer evidence indicates HIV-1 can be acquired through UIA, necessitating revised transmission models.
  • This study explores the impact of role versatility on HIV-1 spread under bidirectional transmission assumptions.

Key Insights:

  • Role versatility significantly increases HIV-1 prevalence among MSM.
  • The assumption of negligible UIA risk is invalid, and bidirectional transmission is a critical factor.
  • Stochastic modeling confirms that role versatility enhances HIV-1 spread even with robust transmission dynamics.

Outlook:

  • Findings underscore the need for tailored HIV prevention strategies for MSM, considering sexual role diversity.
  • Further research should investigate the interplay of condom use, role versatility, and UAI in HIV transmission.
  • Public health interventions must adapt to the complex transmission dynamics within MSM communities.