The hypervitaminosis-A rat: a model for mucin hypersecretion in cystic fibrosis?

Cystic fibrosis is a devastating disease with pathognomonic features typically displayed in the exocrine system. An obvious drawback with human clinical studies of the disease is the relative inaccessibility of its "target-tissues," i.e., the salivary glands, intestine, pancreas, and tracheobronchial tree. Thus, little is known about its underlying cellular mechanisms. For this reason, physiologically relevant animal models for the disease are vitally needed. At present, there are animal models available for certain salivary gland biochemical aspects of the disease and for bicarbonate ion secretory alterations. However, no adequate model exists for excessive mucus production, an aspect of the disease which sets the stage for life-threatening infections and digestive disorders. This manuscript examines morphological and biochemical changes occurring in various biological systems exposed to high levels of vitamin A and correlates such changes with abnormalities commonly seen in cystic fibrosis.