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Bone marrow edema associated with everolimus.
Rachel Lebovic McDevitt1, Chelsey Quinlan2, Katie Hersberger3
1University of Michigan Comprehensive Cancer Center, Ann Arbor, MI rlebovic@med.umich.edu.
Summary
Everolimus, a medication for metastatic pancreatic neuroendocrine tumors (pNET), may cause bone marrow edema and pain. Discontinuation led to rapid symptom resolution, suggesting a probable adverse drug reaction.
Area of Science:
- Oncology
- Pharmacology
- Radiology
Background:
- Metastatic pancreatic neuroendocrine tumors (pNET) are rare and often treated with targeted therapies.
- Everolimus, an mTOR inhibitor, is used in pNET treatment but can have adverse effects.
- Musculoskeletal adverse events associated with mTOR inhibitors require careful monitoring.
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