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Origami Inspired Self-assembly of Patterned and Reconfigurable Particles

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Cell Assembly in Self-foldable Multi-layered Soft Micro-rolls.

Tetsuhiko F Teshima¹, Hiroshi Nakashima², Yuko Ueno²

¹NTT Basic Research Laboratories, NTT Corporation, 3-1 Morinosato-Wakamiya, Atsugi, Kanagawa, 243-0198, Japan. teshima.tetsuhiko@lab.ntt.co.jp.

Scientific Reports

|December 24, 2017

Summary

This summary is machine-generated.

Researchers developed self-folding polymer micro-rolls for 3D cell culture. These biocompatible micro-rolls enable the encapsulation and manipulation of cells, creating functional tissue constructs for potential regenerative medicine applications.

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Area of Science:

Biomaterials Science
Tissue Engineering
Polymer Science

Background:

Multi-layered thin films with varying mechanical properties can self-assemble into complex 3D shapes.
Current methods for 3D cell culture often face challenges in biocompatibility and scalability.

Purpose of the Study:

To develop novel micro-patterned all-polymer films, termed micro-rolls, for in vitro cell encapsulation and manipulation.
To create biocompatible, self-folding 3D tubular architectures for reconstructing living tissues.

Main Methods:

Fabrication of twin-layered polymer films using strain engineering and a self-folding rolling process.
Geometric control of film strain to achieve tunable 3D tubular architectures.
Integration with sacrificial hydrogel layers for high-yield, non-cytotoxic release of micro-rolls.

Main Results:

Successfully created micro-rolls with controllable diameters and high biocompatibility.
Demonstrated the ability to wrap multiple cells within individual micro-rolls.
Reconstructed hollow or fiber-shaped 3D cellular constructs mimicking intrinsic tissue morphology and function.

Conclusions:

The developed micro-roll system offers a versatile platform for 3D cell encapsulation and tissue engineering.
This technology shows potential for creating bio-interfaces for tissue reconstruction and implantable grafts.
The self-folding and biocompatible nature of micro-rolls facilitates the development of functional living tissue constructs.