FRAX-based intervention and assessment thresholds in seven Latin American countries
P Clark1,2, E Denova-Gutiérrez3,4, C Zerbini5
1Clinical Epidemiology Research Unit, Hospital Infantil de México Federico Gomez, Dr. Márquez #164, Col. Doctores, Mexico City, Mexico.
Summary
This study developed age-specific intervention thresholds using the Fracture Risk Assessment (FRAX) tool for seven Latin American countries. Country-specific FRAX models are recommended for better detection of high fracture risk in men and women.
Area of Science:
- Osteoporosis research
- Public health
- Geriatric medicine
Background:
- Osteoporosis poses a significant fracture risk, particularly in aging populations.
- Accurate assessment tools are crucial for identifying individuals needing intervention.
- The Fracture Risk Assessment (FRAX) tool is widely used but requires localized thresholds.
Purpose of the Study:
- To compute FRAX-based intervention and bone mineral density (BMD) assessment thresholds for seven Latin American countries.
- To establish age-specific thresholds for men and women aged 40 years and older.
- To evaluate the utility of FRAX in detecting high fracture risk in diverse populations.
Main Methods:
- Intervention thresholds (IT) were defined based on a 10-year probability of major osteoporotic fracture (MOF).
- Lower and upper assessment thresholds were established relative to the IT.
- Age-specific thresholds were calculated for seven Latin American countries, with or without BMD inclusion.
Main Results:
- Age-specific intervention thresholds varied significantly across the seven Latin American countries.
- Thresholds ranged from 0.6% (Colombia) to 27.5% (Argentina) between ages 40 and 90.
- FRAX demonstrated a substantial advance in detecting high fracture risk, especially in the elderly.
Conclusions:
- Country-specific FRAX models are more appropriate for Latin American countries than a global model.
- The developed age-specific thresholds enhance the detection of individuals at high risk of fragility fracture.
- FRAX-based intervention thresholds represent a significant advancement for osteoporosis management in Latin America.
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