Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Underflow Gates01:30

Underflow Gates

431
Underflow gates are vital for controlling water flow in irrigation canals. The three main types of underflow gates — vertical, radial, and drum gates — serve different purposes while ensuring effective flow management. Vertical gates move up and down, generating a free-flowing water jet; radial gates pivot to regulate the flow; and drum gates rotate for precise adjustments. The flow through these gates is influenced by downstream conditions, resulting in free or drowned outflow.Free and...
431
Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

4.2K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
4.2K
Non-gated Ion Channels01:24

Non-gated Ion Channels

8.3K
Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
8.3K
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

7.8K
Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
7.8K
Design Example: Forces in Sluice Gate01:11

Design Example: Forces in Sluice Gate

3.1K
In hydraulic engineering, sluice gates are essential for managing water flow through channels, reservoirs, and irrigation systems. Sluice gates, acting as vertical barriers, regulate water by adjusting the gate's opening height, which changes the velocity and pressure of water flowing beneath the gate. Understanding the forces involved is crucial to designing sluice gates that can withstand dynamic pressure differences, especially when the gate is closed or partially open.
Key variables in...
3.1K
G-Protein Gated Ion Channels01:21

G-Protein Gated Ion Channels

5.8K
GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory...
5.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Emerging pathogens of ocular infections due to environmental changes-what lies ahead?

Die Ophthalmologie·2026
Same author

Die Ophthalmologie·2026
Same author

[Home or abroad? Potential effects of political change in Syria on doctors in Germany].

Die Ophthalmologie·2026
Same author

[Limbal diseases].

Die Ophthalmologie·2026
Same author

Diurnal Variation in Corneal Stromal and Epithelial Thickness in Fuchs Endothelial Corneal Dystrophy: With and Without Intensified Hypertonic Saline Eyedrop Application.

Cornea·2025
Same author

Waiting is worthwhile: ROP stage 5 with stage regression due to retinal reattachment after scleral buckling surgery (encircling band) - a case report with review of the literature.

BMC ophthalmology·2025

Related Experiment Video

Updated: Feb 16, 2026

P50 Sensory Gating in Infants
12:55

P50 Sensory Gating in Infants

Published on: December 26, 2013

9.6K

[Tintelnotia destructans: new enemy at the gates].

K J Habbe1,2, A Frings3, S Schrader1

  • 1Univ.-Klinik für Augenheilkunde, Heinrich-Heine-Universität Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Deutschland.

Der Ophthalmologe : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft
|December 24, 2017
PubMed
Summary

This study details the second global case of Tintelnotia destructans-associated keratitis, a fungal eye infection. Effective treatment with amphotericin B and voriconazole was confirmed, highlighting the need for thorough diagnostics in rare microbial keratitis cases.

Keywords:
Amphotericin BMycotic keratitisResistogramTerbinafineTintelnotia destructansVoriconazole

More Related Videos

Rapid Assembly of Multi-Gene Constructs using Modular Golden Gate Cloning
08:31

Rapid Assembly of Multi-Gene Constructs using Modular Golden Gate Cloning

Published on: February 5, 2021

15.0K
Ambient Method for the Production of an Ionically Gated Carbon Nanotube Common Cathode in Tandem Organic Solar Cells
14:37

Ambient Method for the Production of an Ionically Gated Carbon Nanotube Common Cathode in Tandem Organic Solar Cells

Published on: November 5, 2014

9.9K

Related Experiment Videos

Last Updated: Feb 16, 2026

P50 Sensory Gating in Infants
12:55

P50 Sensory Gating in Infants

Published on: December 26, 2013

9.6K
Rapid Assembly of Multi-Gene Constructs using Modular Golden Gate Cloning
08:31

Rapid Assembly of Multi-Gene Constructs using Modular Golden Gate Cloning

Published on: February 5, 2021

15.0K
Ambient Method for the Production of an Ionically Gated Carbon Nanotube Common Cathode in Tandem Organic Solar Cells
14:37

Ambient Method for the Production of an Ionically Gated Carbon Nanotube Common Cathode in Tandem Organic Solar Cells

Published on: November 5, 2014

9.9K

Area of Science:

  • Mycology
  • Ophthalmology
  • Infectious Diseases

Background:

  • Tintelnotia destructans, a fungus identified in 2016, is known to cause nail and corneal infections.
  • Fungal keratitis is a serious ocular infection that can lead to vision loss.
  • Atypical microbial keratitis requires comprehensive diagnostic approaches.

Observation:

  • This report presents the second documented case of Tintelnotia destructans-associated keratitis globally.
  • The patient presented with symptoms indicative of fungal keratitis.
  • Diagnostic investigations were crucial for identifying the causative agent and guiding treatment.

Findings:

  • For the first time, a fungal resistogram demonstrated good sensitivity of Tintelnotia destructans to amphotericin B and voriconazole.
  • Successful clinical management of the Tintelnotia destructans-associated keratitis was achieved.
  • The case highlights the efficacy of specific antifungal agents in treating this rare fungal infection.

Implications:

  • This case underscores the importance of advanced diagnostic methods for atypical microbial keratitis.
  • The findings contribute to the understanding of Tintelnotia destructans pathogenicity and treatment options.
  • Early and accurate diagnosis is critical for successful management and visual prognosis in rare fungal keratitis.