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Related Experiment Video

Updated: Feb 16, 2026

Technique to Target Microinjection to the Developing Xenopus Kidney

Technique to Target Microinjection to the Developing Xenopus Kidney

Published on: May 3, 2016

Stereological study of developing glomerular forms during human fetal kidney development.

Marija Dakovic Bjelakovic¹, Slobodan Vlajkovic², Aleksandar Petrovic³

¹Institute of Anatomy, Medical Faculty, University of Nis, Zorana Djindjica 81, Nis, 18000, Serbia. marijadb968@gmail.com.

Pediatric Nephrology (Berlin, Germany)

|December 24, 2017

Summary

This summary is machine-generated.

This study quantifies glomerular development in human fetal kidneys, revealing increasing nephron numbers and changes in developing forms. These findings offer insights into normal kidney morphogenesis crucial for medical practice.

Keywords:

Gestation age Glomerulus Human fetus Kidney Stereology

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Last Updated: Feb 16, 2026

Technique to Target Microinjection to the Developing Xenopus Kidney

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Published on: May 3, 2016

Assessment of Kidney Function in Mouse Models of Glomerular Disease

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Published on: June 30, 2018

High Frequency Ultrasound for the Analysis of Fetal and Placental Development In Vivo

High Frequency Ultrasound for the Analysis of Fetal and Placental Development In Vivo

Published on: November 8, 2018

Area of Science:

Developmental biology
Nephrology
Human embryology

Background:

Human fetal kidney development is a complex, stepwise process.
Glomerular number, shape, size, and distribution are key indicators of kidney organization.
Understanding normal development is vital for clinical applications.

Purpose of the Study:

To quantitatively assess glomerular developing forms during human fetal kidney development.
To utilize stereological methods for precise measurements.
To establish a baseline for normal kidney morphogenesis.

Main Methods:

Analysis of kidney tissue from 40 human fetuses (9-40 weeks gestation).
Grouping specimens into eight 1-lunar-month intervals.
Application of stereological methods at the light microscopy level to estimate glomerular form parameters.

Main Results:

Nephrogenesis advanced throughout gestation, increasing nephron count.
Vesicular and S-shaped bodies decreased as vascularized glomeruli increased.
Glomerular volume and surface density increased, with numerical density peaking at 7 months; nephrogenesis concluded by 36 weeks.

Conclusions:

This study provides quantitative data on human kidney development.
Understanding fetal kidney morphogenesis is important for future medical practice.
Fetal developmental events can have long-term health consequences.