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Challenges and Solution of Invasive Aspergillosis in Non-neutropenic Patients: A Review

Matteo Bassetti1, Maddalena Peghin2, Antonio Vena2

  • 1Infectious Diseases Clinic, Department of Medicine University of Udine, Azienda Sanitaria Universitaria Integrata, Udine, Italy. matteo.bassetti@asuiud.sanita.fvg.it.

Infectious Diseases and Therapy
|December 24, 2017
PubMed

Insights

Invasive aspergillosis (IA) is a growing concern in non-neutropenic patients. This review critically examines the challenges and strategies for managing IA in this vulnerable population.

Area of Science:

  • Medical Mycology
  • Infectious Diseases

Background:

  • Invasive aspergillosis (IA) is an opportunistic infection increasingly seen in non-neutropenic patients.
  • Diagnosis is difficult due to non-specific symptoms and challenges distinguishing colonization from infection.

Purpose of the Study:

  • To provide clinicians with a critical review of managing IA in non-neutropenic patients.

Main Methods:

  • Literature review of IA management in non-neutropenic populations.
  • Critical analysis of diagnostic and therapeutic approaches.

Main Results:

  • IA diagnosis in non-neutropenic patients is hampered by lower test sensitivity.
  • Management requires careful consideration of clinical context and diagnostic uncertainty.

Conclusions:

  • Effective management of IA in non-neutropenic patients necessitates a thorough understanding of diagnostic limitations and tailored therapeutic strategies.
Keywords:
AspergillusBiomarkersGalactomannanInvasive aspergillosisLiver cirrhosisNon-neutropenic patients

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