Related Experiment Videos
Reduced glutamate decarboxylase activity in the subthalamic nucleus in patients with tardive dyskinesia
U Andersson1, J E Häggström, E D Levin
1Psychiatric Research Center, Ulleråker Hospital, Uppsala, Sweden.
Abstract:
Glutamate decarboxylase (GAD) activity was measured in the nuclei of the basal ganglia in patients with neuroleptic-induced tardive dyskinesia (TD) and controls matched for age and premortem state. In five TD patients, who all had a sudden death, a significant decrease in GAD activity was found in the subthalamic nucleus (STN). The lowered GAD activity in the STN may represent a biochemical substrate for neuroleptic-induced TD.