Related Experiment Video
Updated: Feb 16, 2026

Automatic Identification of Dendritic Branches and their Orientation
Published on: September 17, 2021
Branching tryptamines as a tool to tune their antiproliferative activity
Rinat F Salikov1, Konstantin P Trainov1, Irina K Belousova2
1N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospect, 119991 Moscow, Russian Federation.
Abstract:
The influence of a series of tryptamine derivatives on the viability of normal (HEK293) and tumor (HepG2, Jurkat and SH-SY5Y) cells has been evaluated. All tryptamines tested were three different substitution types: C- and N-branching, and indole benzylation. All the derivations enhance the activity of compounds separately, although the effects of different substitutions were not additive. Thus, combinations of C- and N-branchings as well as C-branching and indole benzylation gave little or no increase in activity.
Related Concept Videos
Problem-Solving: Tuning of a Guitar String
The string's wave speed can be regulated by varying the linear density. Tension is the other property that determines the speed of...
Mass Spectrometry: Branched Alkane Fragmentation
Generation of Straight or Branched Actin Filaments
Arp2/3 Complex
Arp2/3 complex is a seven-subunit complex consisting of two proteins similar to actin- Arp2 and Arp3, and five other subunits that help keep Arp2 and Arp3 inactive. When required, the complex is...
Radical Chain-Growth Polymerization: Chain Branching
Co-activators and Co-repressors
tRNA Activation

