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The protective effects of triptolide on age-related bone loss in old male rats

Deqing Luo1, Hongyue Ren2, Huantang Zhang3

  • 1Orthopaedic Center of People's Liberation Army, The Affiliated Southeast Hospital of Xiamen University, Zhangzhou, 363000, Fujian, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|December 24, 2017
PubMed
Abstract

Insights

Triptolide supplementation improved bone microarchitecture and reduced osteoclast number in aged rats, suggesting it may combat age-related bone loss and senile osteoporosis.

Area of Science:

  • Bone biology and aging research.
  • Pharmacological interventions for osteoporosis.

Background:

  • Triptolide is known to inhibit osteoclast formation and bone resorption.
  • The effect of triptolide on age-related bone loss was previously uninvestigated.

Purpose of the Study:

  • To assess the impact of triptolide on bone microstructure and remodeling in aged male rats.
  • To determine triptolide's potential as a therapeutic agent for age-related bone loss.

Main Methods:

  • Aged male rats received daily triptolide (15 μg/kg/d) or saline for 8 weeks.
  • Evaluated lumbar bone mineral density (BMD), micro-CT, fluorochrome labeling (MAR, BFR), osteoclast number (TRAP staining), and plasma markers (osteocalcin, Tracp 5b).

Main Results:

  • Triptolide significantly increased lumbar BMD, bone volume, trabecular thickness, and trabecular number, while decreasing trabecular separation.
  • Triptolide reduced osteoclast number, RANKL expression, and increased OPG expression, despite no significant changes in MAR or BFR.

Conclusions:

  • Triptolide demonstrates a protective effect against age-related bone loss in elderly rats, primarily by reducing osteoclast activity.
  • Triptolide shows promise as a potential therapeutic strategy for senile osteoporosis.
Keywords:
Male ratsOsteoclastOsteoporosisTriptolide

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