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Evaluation of dermal adhesive formulations for topical application.
Flavia Laffleur1, Andreas Bernkop-Schnürch2
1Department of Pharmaceutical Technology, Institute of Pharmacy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Austria; Massachusetts Institute of Technology, Koch Institute for Integrative Cancer Research at MIT, Langer Lab, 77 Massachusetts Ave, Cambridge, MA 02139, USA.
Summary
Researchers developed a novel preactivated polyacrylic acid for enhanced skin adhesion. This new polymer shows over 15-fold improved adhesion, offering potential for topical drug delivery and wound management applications.
Area of Science:
- Pharmaceutical Technology
- Polymer Chemistry
- Biomaterials Science
Background:
- Topical drug delivery faces challenges with excipient stability and skin adhesion.
- Polyacrylic acid is a well-established pharmaceutical polymer.
- Chemical modification can enhance polymer properties for specific applications.
Purpose of the Study:
- To synthesize and characterize a preactivated polyacrylic acid derivative.
- To evaluate the adhesive properties of the modified polymer for enhanced skin delivery.
- To explore its potential in scar and wound management.
Main Methods:
- Chemical modification of polyacrylic acid with sulfhydryl groups.
- Preactivation of the polymer by covalently binding mercaptonicotinic acid.
- Characterization using viscosity measurements.
- Evaluation of skin adhesive properties via tensile strength and bond strength assays.
Main Results:
- The synthesized preactivated polyacrylic acid exhibited significantly improved adhesive properties.
- Adhesion was found to be 15.39-fold higher compared to the unmodified polyacrylic acid.
- Viscosity measurements confirmed the stability of the polymeric conjugates.
Conclusions:
- The designed preactivated polyacrylic acid demonstrates promising potential as an adhesive excipient for topical applications.
- Enhanced skin adhesiveness facilitates improved drug permeation and retention.
- This novel polymer is suitable for scar and wound management, improving therapeutic outcomes.
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