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No. 133-Prevention of Rh Alloimmunization
Karen Fung Kee Fung1, Erica Eason1
1Ottawa, ON.
Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'Obstetrique Et Gynecologie Du Canada : JOGC
|December 25, 2017
Summary
These guidelines offer recommendations for anti-D prophylaxis to prevent rhesus (Rh) alloimmunization in Canadian women. Adherence aims to decrease Rh alloimmunization incidence and standardize immunoprophylaxis practices.
Area of Science:
- Obstetrics and Gynecology
- Immunology
- Maternal-Fetal Medicine
Background:
- Rhesus (Rh) alloimmunization poses a risk during pregnancy.
- Standardized guidelines are needed to optimize prevention strategies.
- The Society of Obstetricians and Gynaecologists of Canada developed these recommendations.
Purpose of the Study:
- To provide evidence-based guidelines for the use of anti-D prophylaxis.
- To optimize the prevention of Rh alloimmunization in Canadian women.
- To minimize practice variations in immunoprophylaxis.
Main Methods:
- A comprehensive literature search of Cochrane Library and MEDLINE (1968-2001) was conducted.
- Search terms included Rho(D) immune globulin, Rh alloimmunization, and pregnancy.
- Evidence was reviewed and quantified by expert committees using established evaluation guidelines.
Main Results:
- The guidelines aim to decrease the incidence of Rh alloimmunization.
- Implementation is expected to minimize practice variations in immunoprophylaxis strategies.
- Key studies supporting recommendations are referenced with evaluative comments.
Conclusions:
- These guidelines have been reviewed and approved by the Maternal-Fetal Medicine and Genetics Committees of the SOGC.
- Input was received from the Rh Program of Nova Scotia.
- Final approval signifies endorsement by the SOGC Executive and Council.
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