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The association between Staphylococcus aureus and subsequent bronchiectasis in children with cystic fibrosis

Daan Caudri1, Lidija Turkovic2, Jolyn Ng2

  • 1Telethon Kids Institute, Perth, Australia; Dept. of Respiratory Medicine, Princess Margaret Hospital, Perth, Australia; Dept. of Pediatrics/Respiratory Medicine, Erasmus MC, Rotterdam, The Netherlands.

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
|December 25, 2017
PubMed

Insights

Early Staphylococcus aureus (S. aureus) infection in children with cystic fibrosis (CF) is linked to lung damage. This finding highlights the importance of monitoring S. aureus in young CF patients for better lung health outcomes.

Area of Science:

  • Pediatric Pulmonology
  • Infectious Diseases
  • Genetics

Background:

  • Staphylococcus aureus (S. aureus) colonization is a concern in cystic fibrosis (CF) patients.
  • The impact of early S. aureus acquisition on CF lung disease progression requires further investigation.

Purpose of the Study:

  • To investigate the association between de novo S. aureus acquisition before school age and lung structure and function in children with CF.

Main Methods:

  • The AREST CF cohort study followed children with CF from diagnosis.
  • Annual bronchoscopies, chest CT scans, and 3-monthly spirometry were performed.
  • Statistical models adjusted for baseline disease severity markers.

Main Results:

  • S. aureus acquisition at age 3 was associated with increased bronchiectasis at ages 5-6.
  • This association persisted after adjusting for confounders.
  • S. aureus at age 3 correlated with reduced FEF25-75, but not FEV1-%-predicted, at ages 5-7.

Conclusions:

  • Early S. aureus acquisition at age 3 is linked to later bronchiectasis and impaired lung function (FEF25-75) in children with CF.
  • These findings underscore the clinical significance of early S. aureus detection and management in pediatric CF care.
Abstract

Keywords:
CT scanInfection and inflammationLung functionStructural lung damage

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