Progress in pharmacological research of chemokine like factor 1 (CKLF1)
Dan-Dan Liu1, Xiu-Yun Song2, Peng-Fei Yang2
1State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Abstract:
Currently, the research of chemokines has penetrated into many fields of life science. A new kind of chemokines, chemokine like factor 1 (CKLF1), which is cloned through suppression subtractive hybridisation (SSH) technology is expressed widely in human body, especially in the lung and peripheral blood leukocytes. CKLF1 has a broad spectrum of chemotaxic activity for many cells, such as lymphocytes, macrophages, bone marrow cells, nerve cells and so on. In addition, CKLF1 also stimulates the regeneration of skeletal muscle cells in vivo. Collecting data derived from our and other laboratories show that CKLF1 has an important relationship with allergic diseases, autoimmune diseases, tumors, cardio-cerebrovascular diseases and so on. Therefore, there be an important theoretical purport and applied value to make a summary of pharmacological progress of CKLF1.
Insights
Chemokine-like factor 1 (CKLF1) is a widely expressed protein with broad cell chemotactic activity and skeletal muscle regeneration properties. CKLF1 research is crucial for understanding allergic, autoimmune, and cardiovascular diseases.
Area of Science:
- Immunology
- Cell Biology
- Regenerative Medicine
Background:
- Chemokines are vital signaling proteins in life sciences.
- Chemokine-like factor 1 (CKLF1) is a newly identified chemokine.
- CKLF1 is broadly expressed, particularly in lung and leukocytes.
Purpose of the Study:
- To summarize the pharmacological progress of CKLF1.
- To highlight the significance of CKLF1 research.
Main Methods:
- Suppression subtractive hybridization (SSH) technology was used for CKLF1 cloning.
- Data from multiple laboratories were collected and analyzed.
Main Results:
- CKLF1 exhibits broad chemotactic activity for lymphocytes, macrophages, bone marrow cells, and nerve cells.
- CKLF1 promotes in vivo skeletal muscle cell regeneration.
- CKLF1 is implicated in allergic diseases, autoimmune diseases, tumors, and cardio-cerebrovascular diseases.
Conclusions:
- CKLF1 possesses significant theoretical and applied value in pharmacology.
- Further research into CKLF1 is warranted due to its diverse biological roles and disease associations.
Related Concept Videos
01:25Factors Influencing Drug Absorption: Disease States and Pharmacology
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
02:07Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:16Transcription Factors
03:08Electrolytes: van't Hoff Factor
The colligative properties of a solution depend only on the number, not on the identity, of solute species dissolved. The concentration terms in the equations for various colligative properties (freezing point depression, boiling point elevation, osmotic pressure) pertain to all solute species present in the solution. Nonelectrolytes dissolve physically without dissociation or any other accompanying process. Each molecule that dissolves yields one...
03:03mTOR Signaling and Cancer Progression
The mTOR pathway or the...
01:28Cholinergic Antagonists: Pharmacological Actions
Gastrointestinal Effects: Antimuscarinics reduce gut contractions, increase gastric emptying, and slow intestinal transit. They partly inhibit gastric acid secretion...