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Updated: Feb 16, 2026

Formulation and Characterization of Bioactive Agent Containing Nanodisks
Published on: March 17, 2023
Extraction, partial characterization and bioactivity of polysaccharides from Senecio scandens Buch.-Ham
Jingbo Yu1, Meiqun Hu1, Yingyao Wang1
1National Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Collaborative Innovation Center of Yangtze River Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, 310014, China.
Abstract:
Mechanochemistry was applied to improve the yield of bioactive acid polysaccharides obtained from low-cost Senecio scandens Buch.-Ham. The structural characteristics and biological activities of three novel polysaccharides from S. scandens (SP2-1, SP2-2 and SP3-2) were investigated. SP2-1 and SP2-2 with molecular weights of 267.6 and 253.1 kDa, respectively, were composed of L-rhamnose, D-arabinose, D-mannose, D-xylose, D-glucose and D-galactose in various ratios, whereas SP3-2 with molecular weight of 266.6 kDa was composed of D-arabinose, D-glucose and D-galactose. In vitro, SP3-2 presented the strongest DPPH, ABTS and O2- radicals scavenging activities, as well as Fe3+ reducibility. Immunological tests demonstrated that all polysaccharide fractions stimulated the production of nitric oxide (NO) and immunomodulatory cytokines (IL-1β and TNF-α) without cytotoxicity in macrophages and promoted splenocyte proliferation in different degree. These findings indicated that SP2-1, SP2-2 and SP3-2 have prominent antioxidant activity and potential immune response, which proved the possibility of S. scandens polysaccharides (SSP) applied in the field of functional food or medicine.
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