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The Association of MMP-8 Genotypes with Pterygium

Pei-Shin Hu1, Wen-Shin Chang2, An-Kuo Chou2,3

  • 1Department of Ophthalmology, Changhua Christian Hospital, Changhua, Taiwan, R.O.C.

In Vivo (Athens, Greece)
|December 25, 2017
PubMed
Abstract

Insights

Genetic variations in matrix metalloproteinase-8 (MMP-8) were not linked to pterygium risk in Taiwanese individuals. These specific MMP-8 polymorphisms do not appear to be major factors in pterygium susceptibility.

Area of Science:

  • Ophthalmology
  • Genetics
  • Biochemistry

Background:

  • Pterygium involves fibrovascular tissue proliferation, influenced by the extracellular microenvironment.
  • Matrix metalloproteinases (MMP) roles in pterygium pathogenesis are understudied.
  • Investigating MMP-8 genetic variations offers insight into pterygium development.

Purpose of the Study:

  • To examine the association of MMP-8 gene polymorphisms with pterygium.
  • To determine if MMP-8 promoter (-799C/T) and coding (Val436Ala, Lys460Thr) variations influence pterygium risk.

Main Methods:

  • Genotyping of 134 pterygium patients and 268 controls using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP).
  • Analysis of three specific MMP-8 polymorphisms: -799C/T, Val436Ala, and Lys460Thr.

Main Results:

  • No significant association was found between the investigated MMP-8 polymorphisms and pterygium risk.
  • Stratified analysis revealed no interaction between MMP-8 genotype, age, or gender in determining pterygium risk.

Conclusions:

  • The studied MMP-8 polymorphisms (-799C/T, Val436Ala, Lys460Thr) may not be significant determinants of individual susceptibility to pterygium.
  • Further research may be needed to explore other genetic or environmental factors in pterygium development.
Keywords:
AgeMMP-8Taiwangendergenotypepolymorphismpterygium

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