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Maternal and Cord Blood Adiponectin Concentrations in Small for Gestational Age: A Meta-Analysis

Eita Goto

    Annals of Nutrition & Metabolism
    |December 25, 2017
    PubMed

    Insights

    Maternal adiponectin levels do not differ in small for gestational age (SGA) infants. However, cord blood adiponectin is significantly lower in SGA infants, indicating a potential role in fetal growth restriction.

    Area of Science:

    • Endocrinology
    • Perinatal Medicine
    • Human Physiology

    Background:

    • Adiponectin is a hormone implicated in insulin sensitivity and growth promotion.
    • Fetal growth is a complex process influenced by various hormonal factors.
    • Small for gestational age (SGA) is a condition where infants are smaller than expected for their gestational age.

    Purpose of the Study:

    • To investigate potential differences in maternal and cord blood adiponectin concentrations between SGA infants and healthy controls.
    • To clarify the role of adiponectin in fetal growth and development.

    Main Methods:

    • A systematic literature search was conducted to identify relevant studies.
    • Meta-analysis was employed to synthesize data on maternal and cord blood adiponectin levels.
    • Standardized Mean Differences (SMDs) were calculated to compare adiponectin concentrations between SGA and control groups.

    Main Results:

    • No significant difference was observed in maternal blood adiponectin concentrations between SGA and healthy control groups (p=0.951).
    • Cord blood adiponectin concentration was significantly lower in SGA infants compared to healthy controls (p=0.028).
    • A large effect size (SMD >0.7) was noted for the difference in cord blood adiponectin.

    Conclusions:

    • Maternal adiponectin levels do not appear to be a distinguishing factor for SGA infants.
    • Lower cord blood adiponectin concentrations in SGA infants suggest a potential association with restricted fetal growth.
    • These findings highlight the importance of cord blood adiponectin as a potential biomarker for SGA.
    Abstract

    Keywords:
    AdiponectinBloodMeta-analysisMothersPregnancySmall for gestational ageUmbilical cord

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