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A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis
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Human milk and necrotizing enterocolitis.

Aloka L Patel1, Jae H Kim2

  • 1Section of Neonatology, Rush University Children's Hospital, 1653 W. Congress Pkwy, Pavilion 353, Chicago, Illinois 60612.

Seminars in Pediatric Surgery
|December 26, 2017
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Summary
This summary is machine-generated.

Human milk feedings significantly reduce the risk of necrotizing enterocolitis (NEC) in preterm infants. This review explores human milk

Keywords:
Donor milkHuman milkNecrotizing enterocolitisPrematurity

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Area of Science:

  • Neonatal Medicine
  • Pediatric Gastroenterology
  • Human Milk Research

Background:

  • Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease in preterm infants, characterized by inflammation and intestinal injury.
  • Multiple overlapping risk factors and stressors contribute to NEC development.
  • Existing research suggests a protective role for human milk in preventing NEC.

Purpose of the Study:

  • To review the protective components present in human milk.
  • To examine clinical evidence supporting the use of human milk for NEC reduction.
  • To identify strategies for increasing human milk utilization in neonatal intensive care units (NICUs).

Main Methods:

  • Literature review of scientific articles and clinical studies.
  • Analysis of research on human milk composition and its biological effects.
  • Examination of clinical trial data on human milk interventions for NEC.

Main Results:

  • Human milk, including mother's own milk and donor milk, is associated with decreased incidence of NEC.
  • Specific bioactive factors in human milk contribute to its protective effects against intestinal injury.
  • Evidence supports the efficacy of human milk in mitigating NEC risk in vulnerable preterm populations.

Conclusions:

  • Human milk is a critical nutritional and immunological resource for preterm infants.
  • Promoting human milk consumption in NICUs is essential for NEC prevention strategies.
  • Further research and implementation of best practices can enhance human milk use and improve infant outcomes.