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Feature-Specific Organization of Feedback Pathways in Mouse Visual Cortex.

Carey Y L Huh1, John P Peach2, Corbett Bennett3

  • 1Department of Comparative Medicine, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA; Department of Neurobiology and Behavior, University of California, Irvine, 2146 McGaugh Hall, Irvine, CA 92697, USA.

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|December 26, 2017
PubMed
Summary
This summary is machine-generated.

Feedback from higher visual areas (AL and PM) to V1 sharpens spatial frequency tuning. Silencing feedback neurons in AL reduced low SF responses, while silencing PM feedback reduced high SF responses in V1.

Keywords:
CAV2-Creanterolateral areaextrastriate cortexfeedbackoptogeneticsposteromedial arearetrograde tracingspatial frequency tuningvisionvisual cortex

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Area of Science:

  • Neuroscience
  • Visual Processing
  • Cortical Circuits

Background:

  • Reciprocal connections exist between higher and lower cortical visual areas.
  • The role of feedback pathways in visual processing, particularly in shaping neuronal tuning for features like spatial frequency, is not well understood.

Purpose of the Study:

  • To investigate the response characteristics of feedback neurons in higher visual areas (AL and PM).
  • To determine how feedback from these areas influences spatial frequency tuning in the primary visual cortex (V1).

Main Methods:

  • Used retrograde viruses for neuronal tracing.
  • Performed targeted electrophysiological recordings in awake, head-fixed mice.
  • Employed optogenetic manipulations to silence specific feedback neurons.

Main Results:

  • Putative feedback neurons in layer 5 of AL and PM showed distinct spatial frequency preferences (AL: 0.04 cpd; PM: 0.15 cpd).
  • Silencing AL feedback neurons reduced responses in V1 neurons preferring low SF (-8.0%).
  • Silencing PM feedback neurons suppressed responses in V1 neurons preferring high SF (-20.4%).

Conclusions:

  • Feedback connections from higher visual areas convey spatially tuned inputs to V1.
  • This "like-to-like" organization boosts V1 neuronal responses to specific spatial frequencies.
  • This functional organization may be a general principle of feedback pathways in sensory systems.