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Related Concept Videos

Review and Preview01:10

Review and Preview

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In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
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Review and Preview01:13

Review and Preview

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Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
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Drug toxicity: Drug–Drug Interaction01:30

Drug toxicity: Drug–Drug Interaction

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Drug–drug interactions can precipitate toxicity through multiple mechanisms. Absorption interactions alter how drugs enter the body, exemplified when ranitidine increases the absorption of basic drugs, while cholestyramine decreases the levels of propranolol. Protein binding interactions occur when drugs share the same binding sites on plasma proteins. Drugs like aspirin and warfarin, when bound in excess, can lead to increased free drug concentrations, enhancing the potential for...
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Pharmacokinetics: Drug–Drug Interactions01:25

Pharmacokinetics: Drug–Drug Interactions

477
Drug interactions occur when the pharmacological effect of one drug is altered by another substance, either enhancing or diminishing its activity. The drug whose activity is altered is known as the object drug, and the substance causing the alteration is called the agent drug or the precipitant. The net effects of these interactions are mostly undesirable, leading to decreased effectiveness or increased adverse effects. In rare cases, interactions can be beneficial, such as the enhanced...
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Bioequivalence of Drugs: Drugs with Multiple Indications01:09

Bioequivalence of Drugs: Drugs with Multiple Indications

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The concept of therapeutic equivalence (TE) in drugs with multiple indications is complex. A generic drug may be therapeutically equivalent to a brand-name product for one specific indication, but this doesn't necessarily mean it's equivalent for all other indications. Evidence of TE in one patient group and bioequivalence shown in healthy volunteers can support—but not confirm—TE for other indications. However, definitive proof requires individual clinical studies for each...
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FDA Approved Drugs: Changes to Approved Drugs01:26

FDA Approved Drugs: Changes to Approved Drugs

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Post-approval, manufacturers may modify an approved new or generic drug product. Such modifications can encompass alterations in the Active Pharmaceutical Ingredient (API), manufacturing process, formulation, batch size, manufacturing site, and container closure system (FDA Guidance for Industry, April 2004). Often, a drug product may undergo multiple changes.These modifications require careful evaluation to determine their potential impact on the drug product's identity, strength, quality,...
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A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
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Formulary Drug Review: Edaravone.

Zaynah K Ali1, Danial E Baker1

  • 1Washington State University, Spokane, WA, USA.

Hospital Pharmacy
|December 26, 2017
PubMed
Summary
This summary is machine-generated.

The Formulary Monograph Service provides monthly drug monographs for Pharmacy & Therapeutics Committees, aiding in drug evaluation and utilization. Subscribers receive online access to customized monographs and drug utilization evaluations for informed decision-making.

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Area of Science:

  • Pharmaceutical Sciences
  • Health Services Research

Background:

  • Pharmacy & Therapeutics (P&T) Committees require timely, evidence-based drug information for formulary decisions.
  • Evaluating drug utilization is crucial for optimizing medication therapy and patient outcomes.

Purpose of the Study:

  • To describe The Formulary Monograph Service, a resource for P&T Committees and healthcare professionals.
  • To highlight the service's components, including drug monographs, summary sheets, and drug utilization evaluations (DUE/MUE).

Main Methods:

  • The service delivers 5-6 detailed monographs on new or late-phase trial drugs monthly.
  • Includes 1-page summary monographs for pharmacy and nursing in-services.
  • Provides comprehensive drug utilization evaluation/medication use evaluation (DUE/MUE) reports.

Main Results:

  • Subscribers gain online access to all provided materials.
  • Monographs can be customized to meet specific facility needs.
  • Selected reviews are published in *Hospital Pharmacy*.

Conclusions:

  • The Formulary Monograph Service offers a valuable, comprehensive resource for drug evaluation and formulary management.
  • The service supports informed decision-making for P&T Committees and facilitates ongoing medication use reviews.