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Related Concept Videos

Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

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The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
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Antimicrobial Proteins01:23

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Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Regulated Protein Degradation02:58

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It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
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Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
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Qualitative and Quantitative Assays for Detection and Characterization of Protein Antimicrobials
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Navigating the New Antimicrobial Stewardship Regulations.

Sondra Davis1, Collin Verheyden2, Mandelin Cooper3

  • 1Medical City Arlington, TX, USA.

Hospital Pharmacy
|December 26, 2017
PubMed
Summary

Implementing effective antimicrobial stewardship programs is crucial for healthcare facilities. Pharmacists play a key role in optimizing patient care and improving antimicrobial use through multidisciplinary collaboration.

Keywords:
anti-infective medicationsantibioticsantimicrobial developmentantimicrobial managementantimicrobial regulationsantimicrobial stewardshipantimicrobial stewardship programimplementation

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Area of Science:

  • Infectious Diseases
  • Hospital Administration
  • Clinical Pharmacy

Background:

  • Healthcare facilities face evolving antimicrobial stewardship standards.
  • New regulations necessitate a review of existing antimicrobial stewardship processes.

Purpose of the Study:

  • To provide guidance for healthcare facilities in establishing and improving antimicrobial stewardship programs.
  • To enhance patient care through better antimicrobial utilization.

Main Methods:

  • Consideration of key personnel involvement.
  • Securing leadership support.
  • Appointing an infectious disease physician to lead the committee.
  • Establishing clear agendas, metrics, and educational strategies.

Main Results:

  • Antimicrobial stewardship is vital in both hospital and community settings.
  • Pharmacists are well-positioned to enhance patient care and stewardship efforts.
  • Multidisciplinary teamwork is essential for improving antimicrobial utilization.

Conclusions:

  • Effective antimicrobial stewardship programs are critical for optimal patient outcomes.
  • Pharmacists contribute significantly to antimicrobial stewardship through clinical activities and collaboration.
  • These initiatives can lead to improved antimicrobial agent utilization and patient safety.