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Related Concept Videos

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

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Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
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Vitamins01:30

Vitamins

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Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
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Oral Cavity01:11

Oral Cavity

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The oral cavity, or the mouth, is a complex structure in humans that plays a vital role in our day-to-day lives. Its role is not only in chewing and swallowing food; it also plays a role in speech and facial expressions.
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...
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Role of Skin in Vitamin D Synthesis01:23

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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
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Electrolytes are essential minerals and ions primarily obtained from the diet and absorbed through the gastrointestinal tract. Most electrolytes are absorbed in the small intestine. While the absorption of iron and calcium primarily occurs in the duodenum, calcium is also absorbed in the jejunum and ileum. In these regions, passive diffusion contributes to its absorption alongside active transport mechanisms in the duodenum. These ions can exit the enterocytes through specialized active...
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Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
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Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
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Use of Micropipette-Guided Drug Administration as an Alternative Method to Oral Gavage in Rodent Models
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Administration of Injectable Vitamin K Orally.

Janna Afanasjeva1

  • 1University of Illinois at Chicago, USA.

Hospital Pharmacy
|December 26, 2017
PubMed
Summary
This summary is machine-generated.

Injectable vitamin K (phytonadione) can be safely administered orally, offering an effective alternative to oral tablets. This approach addresses issues with oral tablet availability and high costs, providing healthcare systems with a viable option.

Keywords:
compoundinginjectableoral administrationphytonadionestabilityvitamin K

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Area of Science:

  • Pharmacology
  • Drug Administration
  • Healthcare Management

Background:

  • Oral vitamin K (phytonadione) tablets have limitations including single dose strength and significant cost increases.
  • There is a need for alternative oral vitamin K formulations due to these drawbacks.

Purpose of the Study:

  • To evaluate the efficacy and safety of using injectable vitamin K formulations for oral administration.
  • To explore a cost-effective alternative to standard oral vitamin K tablets.

Main Methods:

  • A comprehensive literature search was conducted using PubMed and Embase databases.
  • Keywords included various combinations of 'vitamin K,' 'phytonadione,' 'injectable,' 'intravenous,' and 'oral' administration.
  • Six studies and one cost-savings project were analyzed for efficacy and administration methods.

Main Results:

  • Injectable vitamin K administered orally is both effective and safe.
  • Formulations can be prepared as undiluted or compounded solutions, with varying beyond-use dates.
  • This method presents a practical alternative for healthcare providers.

Conclusions:

  • Oral administration of injectable vitamin K provides a safe and effective option.
  • This alternative is particularly valuable when oral vitamin K tablets are scarce or too expensive.
  • Healthcare systems can benefit from this formulation for improved patient care and cost management.