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Pretreatment Serum MCP-1 Level Predicts Response to Risperidone in Schizophrenia
Yezhe Lin1,2, Yanmin Peng1,2, Cuizhen Zhu1,2
1Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shanghai Archives of Psychiatry
|December 26, 2017
Summary
Elevated baseline levels of monocyte chemoattractant protein-1 (MCP-1) in schizophrenia patients predict poor response to risperidone, but not olanzapine, suggesting MCP-1 as a potential biomarker for antipsychotic treatment selection.
Area of Science:
- Neuroscience
- Psychiatry
- Immunology
Background:
- Schizophrenia is a severe mental disorder potentially linked to inflammatory cytokines.
- Few studies have explored cytokine prediction of antipsychotic treatment response.
Purpose of the Study:
- To determine if baseline cytokine levels predict treatment response in schizophrenia patients.
- To investigate the role of specific cytokines (IL-1β, TNF-α, MCP-1) in predicting response to olanzapine and risperidone.
Main Methods:
- Compared serum cytokine levels (IL-1β, TNF-α, MCP-1) in schizophrenia patients and healthy controls.
- Assessed the impact of baseline cytokine levels on psychopathology reduction (PANSS-G) after monotherapy with olanzapine or risperidone.
Main Results:
- Schizophrenia patients had significantly higher baseline MCP-1 levels than controls.
- Pretreatment MCP-1 levels negatively correlated with PANSS-G reduction in risperidone treatment, but not olanzapine.
- Higher baseline MCP-1 predicted poorer response to risperidone, identified via regression analysis.
Conclusions:
- MCP-1 may be involved in schizophrenia pathogenesis.
- Baseline MCP-1 levels could serve as a biomarker for predicting risperidone treatment response in schizophrenia.
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