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Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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The psychodynamic perspective in psychology asserts that most personality functions operate unconsciously, outside of awareness. This means that the motives and emotions driving behavior often remain hidden, automatically buried in the unconscious mind as a defense mechanism to shield us from psychological distress. According to this theory, the unconscious mind contains thoughts, memories, and emotions that are too disturbing to face directly.
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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
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Asthma-IV: Diagnostic and Management01:30

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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Asthma-II: Pathophysiology and Classification01:26

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Related Experiment Video

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Acupuncture in a Rat Model of Asthma
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CRTH2 antagonists in asthma: current perspectives.

Dave Singh1, Arjun Ravi1, Thomas Southworth1

  • 1Division of Infection, Immunity and Respiratory Medicine, The Medicines Evaluation Unit, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, The University of Manchester, Manchester, UK.

Clinical Pharmacology : Advances and Applications
|December 26, 2017
PubMed
Summary
This summary is machine-generated.

Chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) antagonists show promise for treating eosinophilic asthma. These drugs offer a potential alternative to biological therapies for severe asthma cases.

Keywords:
CRTH2clinical trialeosinophilic asthmaprostaglandin D2

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Area of Science:

  • Allergy and immunology
  • Respiratory medicine
  • Pharmacology

Background:

  • Chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) binds prostaglandin D2.
  • CRTH2 is implicated in allergic inflammation and eosinophil activation.
  • CRTH2 is found on eosinophils, mast cells, and basophils.

Purpose of the Study:

  • To review clinical evidence for CRTH2's role in asthma.
  • To examine clinical trials of CRTH2 antagonists for asthma treatment.
  • To discuss future perspectives for CRTH2 antagonists in severe asthma.

Main Methods:

  • Review of clinical evidence on CRTH2 in asthma pathophysiology.
  • Analysis of clinical trial data for CRTH2 antagonists in asthma.
  • Consideration of patient subgroup selection for optimal treatment response.

Main Results:

  • CRTH2 antagonists are in clinical development for asthma treatment.
  • Clinical data suggest CRTH2 antagonists are most effective for eosinophilic asthma.
  • CRTH2 antagonists may offer an alternative to biological treatments for severe asthma.

Conclusions:

  • CRTH2 antagonists represent a potential therapeutic strategy for asthma.
  • Targeting CRTH2 is particularly relevant for eosinophilic asthma.
  • Further research is needed to identify patient subgroups most likely to benefit.