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Cerebellar atrophy following acute intoxication with phenytoin
H Masur1, C E Elger, A C Ludolph
1Department of Neurology, University of Münster, FRG.
Neurology
|March 1, 1989
Abstract:
A patient developed marked cerebellar atrophy after a single suicidal intoxication with 7 grams phenytoin. The clinical signs of cerebellar dysfunction subsided very slowly and incompletely within 18 months. We documented the cerebellar atrophy by CTs 4 weeks and 1 year after the intoxication, and we suggest that a single severe acute intoxication with phenytoin may directly cause cerebellar degeneration.