Compositional dependency on dissolution rate and cytocompatibility of phosphate-based glasses: Effect of B₂O₃ and...

The unique property of phosphate-based glasses and fibres to be completely dissolved in aqueous media is largely dependent on the glass composition. This article focuses on investigating the effect of replacing Na₂O with 3 and 5 mol% Fe₂O₃ on cytocompatibility, thermal and dissolution properties of P₂O₅-CaO-Na₂O-MgO-B₂O₃ glass system, where P₂O₅ content was fixed at 45 mol%. The effect of increasing Fe₂O₃ from 3 to 5 mol% on P₂O₅-CaO-Na₂O-MgO glasses was also evaluated. The glass transition temperature, onset of crystallisation temperature and liquidus temperature were found to decrease with increasing Fe₂O₃ content and the addition of B₂O₃, while the thermal expansion values were found to decrease. The density of the glasses decreased with increasing Fe₂O₃ content. However, an increase in the density was observed by the addition of 5 mol% B₂O₃. The dissolution properties and mode of bulk glass and fibres were also examined which were found to decrease with increasing B₂O₃ and Fe₂O₃. However, it was found that the dissolution properties of the glasses containing both B₂O₃ and Fe₂O₃ were lower than only Fe₂O₃ containing glasses. The in vitro cell culture studies using human osteoblast like (MG63) cell lines revealed that the glasses containing both B₂O₃ and Fe₂O₃ maintained and showed higher cell viability as compared to the only Fe₂O₃ containing glasses. Glasses containing both B₂O₃ and Fe₂O₃ showed a pronounced effect on the dissolution rate of the glasses, which eventually improved the cytocompatibility properties of the glasses investigated.