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Polypoidal Choroidal Vasculopathy.

Joon-Bom Kim1, Rajinder S Nirwan1, Ajay E Kuriyan1

  • 1Flaum Eye Institute, University of Rochester Medical Center, Rochester, NY, USA.

Current Ophthalmology Reports
|December 26, 2017
PubMed
Summary
This summary is machine-generated.

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Polypoidal choroidal vasculopathy (PCV) affects Asians and African-Americans, presenting with macular nodules. Combination therapy of photodynamic therapy (PDT) and anti-vascular endothelial growth factor (VEGF) shows superior outcomes for PCV management.

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Vascular Biology

Background:

  • Polypoidal choroidal vasculopathy (PCV) is a subtype of age-related macular degeneration.
  • PCV is characterized by abnormal vascular networks and polyp-like structures under the retina.

Purpose of the Study:

  • To review recent literature on polypoidal choroidal vasculopathy (PCV).
  • To provide an update on the epidemiology, pathophysiology, clinical findings, and management of PCV.

Main Methods:

  • Literature review of recent studies on PCV.
  • Analysis of diagnostic imaging modalities including indocyanine-green angiography (ICGA), en face optical coherence tomography (OCT), and OCT angiography (OCT-A).
  • Evaluation of treatment outcomes for various therapeutic approaches.
Keywords:
age-related macular degenerationchoroidal neovascularizationophthalmologypolypoidal choroidal vasculopathy

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Main Results:

  • Indocyanine-green angiography (ICGA) remains the gold standard for PCV diagnosis.
  • En face OCT and OCT angiography are valuable non-invasive tools for identifying PCV lesions.
  • Combination therapy of photodynamic therapy (PDT) and anti-vascular endothelial growth factor (VEGF) demonstrates superior treatment outcomes compared to monotherapy.

Conclusions:

  • PCV predominantly affects Asian and African-American populations, often presenting with an orange-red nodule.
  • While ICGA is definitive, OCT-A and en face OCT offer non-invasive diagnostic capabilities for PCV.
  • Combined PDT and anti-VEGF therapy is the most effective treatment strategy for PCV, with ongoing research into new OCT modalities and anti-VEGF agents.