Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

1.0K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.0K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.3K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.3K
Glaucoma: Overview01:25

Glaucoma: Overview

1.4K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.4K
Contact Angle01:13

Contact Angle

26.6K
When a solid is dipped inside a liquid, the liquid surface becomes curved near the contact. For some solid–liquid interfaces, the liquid is pulled up along the solid, while for others, the liquid surface is convex or depressed near the solid surface. This phenomenon can be explained using the concept of cohesive and adhesive forces.
The adhesive force is the molecular force between molecules of different materials, that is, between the molecules of the solid and the liquid. The cohesive...
26.6K
Genetics of Speciation02:16

Genetics of Speciation

22.0K
Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
22.0K
What is Population Genetics?01:25

What is Population Genetics?

65.0K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
65.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Can we identify people with Alzheimer's disease from examination of the eye? A bidirectional Mendelian randomization (MR) study.

The journal of prevention of Alzheimer's disease·2026
Same author

Tobacco smoking disrupts bile acid and tryptophan metabolism in multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same author

A Primary Open-Angle Glaucoma Locus Near Transcription Factor <i>PRRX1</i> Identified in the Million Veteran Program.

Ophthalmology science·2026
Same author

Associations between perfluoroalkyl substances and multiple sclerosis in U.S. cohorts compared with NMOSD, MOGAD, and healthy controls.

Environmental research·2026
Same author

Clinical and demographic characteristics of glaucoma patients in Kingston, Jamaica.

International ophthalmology·2026
Same author

"I want to see everything": A community-based participatory research framework to identify eye health and vision care knowledge, perceptions, values, and barriers.

Journal of clinical and translational science·2026

Related Experiment Video

Updated: Feb 16, 2026

Collecting Hair Samples for Hair Cortisol Analysis in African Americans
06:01

Collecting Hair Samples for Hair Cortisol Analysis in African Americans

Published on: June 10, 2018

19.4K

Primary Open-Angle Glaucoma Genetics in African Americans.

Nicole A Restrepo1, Jessica N Cooke Bailey1

  • 1Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH.

Current Genetic Medicine Reports
|December 26, 2017
PubMed
Summary

Primary open-angle glaucoma (POAG) disproportionately affects individuals of African descent. Genetic research in this population is lacking, with European POAG variants not yet replicated in African Americans.

Keywords:
African American primary open angle glaucomaglaucoma genetics

More Related Videos

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.9K
Applications of RNA Interference in American Cockroach
06:32

Applications of RNA Interference in American Cockroach

Published on: December 17, 2021

2.9K

Related Experiment Videos

Last Updated: Feb 16, 2026

Collecting Hair Samples for Hair Cortisol Analysis in African Americans
06:01

Collecting Hair Samples for Hair Cortisol Analysis in African Americans

Published on: June 10, 2018

19.4K
Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.9K
Applications of RNA Interference in American Cockroach
06:32

Applications of RNA Interference in American Cockroach

Published on: December 17, 2021

2.9K

Area of Science:

  • Ophthalmology
  • Genetics
  • Public Health

Background:

  • Primary open-angle glaucoma (POAG) is a leading cause of blindness globally.
  • Individuals of African descent exhibit the highest risk for developing POAG.
  • There is a significant knowledge gap regarding the genetic and environmental factors contributing to POAG in this population.

Purpose of the Study:

  • To review the current literature on the genetics of POAG in African Americans.
  • To highlight the need for further research into POAG etiology in at-risk populations.

Main Methods:

  • Literature review of existing studies on POAG genetics in African Americans.
  • Analysis of current findings regarding genetic variants and clinical features.

Main Results:

  • European POAG index variants (e.g., CDKN2B-AS1, SIX1/SIX6) have not been replicated in African Americans.
  • These European loci cannot be definitively excluded as contributing to POAG risk in individuals of African descent.
  • Recent research is exploring clinical features that may explain POAG risk disparities between African Americans and European Americans.

Conclusions:

  • Limited progress has been made in understanding the genetic basis of POAG in African Americans and other individuals of African descent.
  • Further investigation is crucial to identify specific genetic and environmental factors driving POAG risk in this demographic.