Related Experiment Video
Updated: Feb 16, 2026

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes
Published on: February 28, 2025
The long-term neurodevelopmental outcomes of infants born full-term with low birth weight
Ayşe Tosun1, Börte Gürbüz-Özgür2, Hatice Aksu3
1Departments of Pediatric Neurology, Adnan Menderes University Faculty of Medicine, Aydın.
Insights
Infants born small for gestational age (SGA) may experience long-term neurodevelopmental challenges. These include delayed milestones, lower IQ, and increased ADHD symptoms, impacting school success and behavior.
Area of Science:
- Pediatrics
- Neurodevelopment
- Child Psychology
Background:
- Small for gestational age (SGA) infants are born at or after 37 weeks with birth weights below the tenth percentile.
- Long-term neurodevelopmental outcomes in SGA children require further investigation.
Purpose of the Study:
- To evaluate the long-term neurological development, school success, intelligence quotient (IQ), and attention deficit hyperactivity disorder (ADHD) symptoms in children born SGA.
- To compare these outcomes with a healthy control group.
Main Methods:
- A cohort of 74 SGA children and 75 healthy controls were assessed by child neurologists and psychiatrists.
- Standardized assessments included the Wechsler Intelligence Scale for Children-Revised, Ankara Developmental Screening Inventory, and T-DSM-IV-S.
Main Results:
- SGA children showed shorter breastfeeding duration, later walking and talking, and more vision disorders.
- SGA cases had higher incidence of febrile convulsions, delayed mental development, lower school success, and higher ADHD diagnosis rates.
- SGA children exhibited lower scores on inattention and conduct disorder subscales of the T-DSM-IV-S.
Conclusions:
- Being born small for gestational age (SGA) is associated with negative long-term impacts on a child's behavior, attention, and academic achievement.
- Early identification and intervention may be crucial for mitigating these developmental challenges in SGA populations.
Abstract:
Tosun A, Gürbüz-Özgür B, Aksu H, Kaynak-Türkmen M. The long-term neurodevelopmental outcomes of infants born full-term with low birth weight. Turk J Pediatr 2017; 59: 169-176. In this study, it was aimed to evaluate the neurological developments of pre-school or school-aged children together with their school successes, intelligence quotient and symptom severity of attention deficit hyperactivity disorder who were born at the 37th gestational week and above with birth weights below tenth percentile, which is called small for gestational age (SGA). A total of 74 patients with SGA and 75 healthy children were evaluated. The patients were evaluated by child neurologist and child psychiatrist. Wechsler Intelligence Scale for Children-Revised, Ankara Developmental Screening Inventory, and The Turgay DSM-IV-Based Child and Adolescent Disruptive Behavioral Disorders Screening and Rating Scale (T-DSM-IV-S) were applied according to their age groups. SGA cases had been breastfed for shorter durations (p: 0.004), had walked later (p < 0.001), talked later (p < 0.001), and had encountered more vision disorders (p: 0.009) than the control group. SGA cases were determined to encounter febrile convulsions more frequently (p: 0.007). SGA cases were determined to exhibit lower school success (p < 0.001), were diagnosed with attention deficit hyperactivity disorder more frequently (p < 0.001), and their mental developments were delayed (p < 0.001). In cases with SGA, inattention (p: 0.004) and conduct disorder (p: 0.029) subscales and the total scale scores (p: 0.022) of T-DSM-IV-S were significantly lower when compared to the control group. We consider that being SGA may have a negative impact on child`s behavior, attention and academic achievement in long-term.
More Related Videos
07:26Isolation and Characterization of Human Umbilical Cord-derived Mesenchymal Stem Cells from Preterm and Term Infants
Published on: January 26, 2019
05:34A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction
Published on: July 18, 2025
Related Concept Videos
Long-term Depression
Long-term Depression
Calcium Ion Concentration Mechanism
If over...
Long-term Potentiation
Long-term Potentiation
Hebbian LTP
LTP can occur when...
Directional Terms
Long-Term Memory
Long-term memory can be categorized into two primary types: explicit and implicit memory. Explicit memory, also known as declarative memory, involves the conscious recollection of information that we deliberately try to remember, recall, and articulate. This type of memory encompasses specific facts, events, and...