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[Left ventricular dysfunction in hypertensive heart: Current view of the pathogenesis and treatment]

F T Ageev1, A G Ovchinnikov1, M V Ozhereljeva1

  • 1Federal State Budgetary Institution, "Russian Cardiology Science and Production Center" of the Ministry of Health of the Russian Federation.

Kardiologiia
|December 26, 2017
PubMed

Insights

This study explores how high blood pressure leads to left ventricular dysfunction and outlines current treatment strategies for heart failure with preserved ejection fraction, considering its underlying causes.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Heart Failure Studies

Background:

  • Hypertensive heart disease is a significant cause of cardiovascular morbidity.
  • Left ventricular dysfunction is a key complication in patients with hypertension.
  • Heart failure with preserved ejection fraction (HFpEF) presents unique challenges in management.

Purpose of the Study:

  • To elucidate the primary mechanisms driving left ventricular dysfunction in hypertensive patients.
  • To review contemporary treatment trends for HFpEF based on current pathogenetic understanding.

Main Methods:

  • Review of existing literature on hypertensive heart disease.
  • Analysis of pathogenetic mechanisms of left ventricular dysfunction.
  • Synthesis of current therapeutic approaches for HFpEF.

Main Results:

  • Identified key pathophysiological pathways contributing to left ventricular dysfunction in hypertension.
  • Summarized evolving treatment strategies for HFpEF, emphasizing pathogenetic insights.

Conclusions:

  • Understanding the mechanisms of left ventricular dysfunction is crucial for managing hypertensive heart disease.
  • Current treatment trends for HFpEF are increasingly informed by its complex pathogenesis.

Keywords:
arterial hypertension, left ventricle hypertrophy, diastolic dysfunction, heart failure with preserved ejection fraction, systolic dysfunction

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