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[Pathogenetic and Prognostic Role of Growth Factors in the Development of Chronic Heart Failure]

A T Teplyakov1, E N Berezikova2, S N Shilov2

  • 1Federal State Budgetary Science Institution "Tomsk Research Institute of Cardiology of the Siberian Branch of the Russian Academy of Science".

Kardiologiia
|December 26, 2017
PubMed

Insights

Growth factors like vascular endothelial growth factor (VEGF), platelet-derived growth factor AB (PDGF-AB), and basic fibroblast growth factor (FGF-basic) are key in chronic heart failure (CHF) progression in ischemic heart disease (IHD). Their serum levels correlate with CHF severity and patient outcomes.

Area of Science:

  • Cardiology
  • Biochemistry
  • Molecular Biology

Background:

  • Chronic heart failure (CHF) in ischemic heart disease (IHD) presents complex pathophysiological mechanisms.
  • Growth factors are implicated in cardiovascular health and disease progression.

Purpose of the Study:

  • To investigate the role of vascular endothelial growth factor (VEGF), platelet-derived growth factor AB (PDGF-AB), and basic fibroblast growth factor (FGF-basic) in CHF patients with IHD.
  • To determine the correlation between serum levels of these growth factors and the severity and progression of CHF.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) was used to measure serum levels of VEGF, PDGF-AB, and FGF-basic.
  • 94 patients with CHF and 32 controls were included in the study.
  • Measurements were taken at baseline and after 12 months of follow-up.

Main Results:

  • VEGF, PDGF-AB, and FGF-basic are significantly involved in the pathogenesis and progression of heart failure in IHD.
  • Serum levels of VEGF and FGF-basic decrease as CHF progresses, while PDGF-AB levels increase.
  • Low initial VEGF, low FGF-basic, and high PDGF-AB in men indicate a less favorable CHF course.

Conclusions:

  • Serum concentrations of VEGF, PDGF-AB, and FGF-basic are correlated with the severity and clinical course of CHF in IHD patients.
  • These growth factors may serve as biomarkers for predicting adverse cardiovascular events in this patient population.
Abstract

Keywords:
chronic heart failuregrowth factorsischemic heart disease

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