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Updated: Feb 16, 2026

Light-Controlled Fermentations for Microbial Chemical and Protein Production
Published on: March 22, 2022
The yeast stands alone: the future of protein biologic production
Kerry R Love1, Neil C Dalvie1, J Christopher Love1
1Massachusetts Institute of Technology, Department of Chemical Engineering, Koch Institute for Integrative Cancer Research at 500 Main Street, Cambridge, MA 02139, USA.
Abstract:
Yeasts are promising alternative hosts for the manufacturing of recombinant protein therapeutics because they simply and efficiently meet needs for both platform and small-market drugs. Fast accumulation of biomass and low-cost media reduce the cost-of-goods when using yeast, which in turn can enable agile, small-volume manufacturing facilities. Small, tractable yeast genomes are amenable to rapid process development, facilitating strain and product quality by design. Specifically, Pichia pastoris is becoming a widely accepted yeast for biopharmaceutical manufacturing in much of the world owing to a clean secreted product and the rapidly expanding understanding of its cell biology as a host organism. We advocate for a near term partnership spanning industry and academia to promote open source, timely development of yeast hosts.
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