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Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
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Behavioral tagging: Synaptic event or cellular alteration?

Volker Korz1

  • 1Medical University of Vienna, Brain Research Center, Vienna, Austria.

Neurobiology of Learning and Memory
|December 27, 2017
PubMed
Summary
This summary is machine-generated.

Behavioral studies suggest synaptic tagging and capture (STCH) aids long-term memory. However, alternative explanations involving neuronal intrinsic excitability (IE) changes may also account for these memory formation findings.

Keywords:
Intrinsic excitabilityMemoryPlasticitySynaptic tag

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Molecular Biology

Background:

  • The synaptic tagging and capture hypothesis (STCH) explains memory consolidation.
  • Recent studies explore STCH's role in intact animal learning and memory.

Purpose of the Study:

  • To evaluate if behavioral observations support STCH for memory formation.
  • To consider alternative non-synaptic mechanisms, like intrinsic excitability (IE), in memory consolidation.

Main Methods:

  • Analysis of behavioral studies on hippocampus-dependent memory tasks.
  • Comparison of STCH predictions with alternative explanations based on neuronal plasticity.

Main Results:

  • Behavioral tagging experiments show results consistent with STCH.
  • These findings can also be explained by changes in neuronal intrinsic excitability (IE).

Conclusions:

  • Behavioral data alone does not confirm synaptic mechanisms for memory.
  • Neuronal intrinsic excitability (IE) offers a plausible alternative to STCH in memory formation.