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Updated: Feb 16, 2026

Dissection and Culture of Commissural Neurons from Embryonic Spinal Cord
Published on: May 25, 2010
Commissural axon navigation in the spinal cord: A repertoire of repulsive forces is in command
Hugo Ducuing1, Thibault Gardette1, Aurora Pignata1
1University of Lyon, University of Lyon 1 Claude Bernard Lyon1, NeuroMyoGene Institute, CNRS UMR5310, INSERM U1217, 16 rue Raphael Dubois, F-69000 Lyon, France.
Abstract:
The navigation of commissural axons in the developing spinal cord has attracted multiple studies over the years. Many important concepts emerged from these studies which have enlighten the general mechanisms of axon guidance. The navigation of commissural axons is regulated by a series of cellular territories which provides the diverse guidance information necessary to ensure the successive steps of their pathfinding towards, across, and away from the ventral midline. In this review, we discuss how repulsive forces, by propelling, channelling, and confining commissural axon navigation, bring key contributions to the formation of this neuronal projection.
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