Related Experiment Video
Updated: Feb 16, 2026

Stereotactic Radiosurgery for Gynecologic Cancer
Published on: April 17, 2012
Stereotactic Radiosurgery Alone for One to Two Brain Metastases from Cancer of Unknown Primary
Liesa Dziggel1, Amira Bajrovic2, Steven E Schild3
1Department of Radiation Oncology, University of Lübeck, Lübeck, Germany.
Background/Aim:
The use of stereotactic radiosurgery (SRS) alone has become popular for treating patients with a limited number of brain metastases. In very few patients, the primary tumor leading to cerebral spread is unknown. This study investigated the role of SRS for this rare situation.
Patients And Methods:
Eight patients with 1-2 brain metastases from cancer of unknown primary (CUP) received SRS alone (median dose 20 Gy). Five clinical factors were evaluated for association with local control of the irradiated lesions, freedom from new cerebral lesions and survival.
Results:
Six-month and 12-month survival rates were 63% and 63%, respectively. Improved survival was associated with male gender and only one cerebral lesion. Local control rates at 6 and 12 months were 100%. Six-month rate of freedom from new cerebral lesions was 86%.
Conclusion:
SRS appeared effective and resulted in promising local control and survival rates in patients with 1-2 brain metastases from CUP.
Related Concept Videos
Testing a Claim about Mean: Unknown Population SD
Estimating a population mean requires the samples to be approximately normally distributed. The data should be collected from the randomly selected samples having no sampling bias. There is no specific requirement for sample size. But if the sample size is less than 30, and we don't know the population standard deviation, a different approach is used;...
Estimating Population Mean with Unknown Standard Deviation
William S. Gosset (1876–1937) of the...
Primary Active Transport
Primary and Secondary Growth in Roots and Shoots
Primary Production
Primary Distribution

