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Updated: Feb 16, 2026

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
Published on: August 9, 2022
Formulation and Evaluation of Novel Solid Lipid Microparticles for the Sustained Release of Ofloxacin
Aashima Hooda1, M Sradhanjali1, Popsy1
1PDM College of Pharmacy, Sector-3A Bahadurgarh, Haryana, India.
Objective:
The aim of this study was to prepare solid lipid microparticles (SLM) with incorporated ofloxacin, suitable for oral delivery.
Methods:
Ofloxacin-loaded SLM were prepared using stearic acid and chloroform as lipid matrix and Tween-80 as surfactant, by high shear homogenization technique and followed by lyophilization. The physiochemical characterization of SLMs were investigated by scanning electron microscopy, transmission electron microscopy, zeta potential, zone of inhibition, in-vitro study, ex-vivo study and stability study.
Results:
The result demonstrated that the entrapment efficiency, particle size and zeta potential of microparticles were 86.02%, 203.7nm and -32.68mv, respectively. The in-vitro and ex-vivo studies showed sustained release of drug from formulation.
Conclusion:
These results indicate that SLM might be a promising delivery system to enhance the pharmacological activity of ofloxacin.
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