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Updated: Feb 16, 2026
12:13
Ex Situ Normothermic Machine Perfusion of Donor Livers
Published on: May 26, 2015
12.3K
Hypothermic machine perfusion in liver transplantation
R Cutler Quillin1, James V Guarrera1
1From the Center for Liver Disease and Transplantation, Department of Surgery, Columbia University Medical Center, New York, NY.
Summary
Marginal liver allografts are increasingly used due to donor organ shortages. Hypothermic machine perfusion may improve outcomes and expand the donor pool for liver transplantation.
Area of Science:
- Hepatology
- Transplantation Medicine
- Surgical Innovation
Background:
- Limited donor organ availability necessitates the use of marginal liver allografts.
- Marginal allografts carry increased risks of primary nonfunction and early dysfunction.
- Ischemia/reperfusion injury is a significant concern in liver preservation.
Purpose of the Study:
- To review the clinical experience with hypothermic machine perfusion (HMP) in human liver transplantation.
- To assess the potential of HMP to mitigate risks associated with marginal liver allografts.
- To evaluate HMP's role in expanding the donor pool for liver transplantation.
Main Methods:
- Review of clinical data and major experiences with hypothermic machine perfusion preservation.
- Analysis of outcomes in liver transplant recipients receiving HMP-preserved allografts.
- Examination of the impact of HMP on allograft quality and recipient complications.
Main Results:
- Hypothermic machine perfusion is an emerging technology for liver preservation.
- HMP shows promise in limiting ischemia/reperfusion injury.
- Clinical experience suggests HMP may lead to improved post-transplant outcomes.
Conclusions:
- Hypothermic machine perfusion is a viable strategy for preserving liver allografts.
- Increased utilization of HMP may allow for acceptance of more marginal organs.
- HMP has the potential to expand the donor pool and improve liver transplant success rates.
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