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Discerning the relationship between left ventricular geometry, high-sensitivity troponin T, and nondipper

Lutfu Askin1, Hakan Tasolar1, Ugur Aksu2

  • 1Department of Cardiology, Adiyaman Training and Research Hospital, Adiyaman.

Blood Pressure Monitoring
|December 27, 2017
PubMed

Insights

High-sensitivity cardiac troponin T (hs-cTnT) is elevated in nondipper hypertension (NDH) and predicts this condition. This biomarker may aid in diagnosing NDH in hypertensive patients.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Biomarker Discovery

Background:

  • Hypertension can lead to left ventricular structural changes and abnormal geometry.
  • Elevated high-sensitivity cardiac troponin T (hs-cTnT) levels correlate with left ventricular hypertrophy in hypertensive individuals.

Purpose of the Study:

  • To evaluate the diagnostic utility of hs-cTnT in patients with nondipper hypertension (NDH).
  • To determine the association between left ventricular geometric patterns and hs-cTnT levels in hypertensive patients.

Main Methods:

  • 100 hypertensive patients were classified into dipper (n=63) and nondipper (n=37) hypertension groups.
  • hs-cTnT levels were measured once upon admission.
  • Echocardiography was performed at baseline and 6 months to assess left ventricular geometry.

Main Results:

  • hs-cTnT levels were significantly higher in the NDH group (P<0.001).
  • hs-cTnT strongly correlated with nondipping status (r=0.747, P<0.001) and independently predicted NDH.
  • An hs-cTnT level >0.95 ng/L predicted NDH with 75% sensitivity and 98% specificity (AUC=0.86).

Conclusions:

  • Patients with NDH exhibit elevated hs-cTnT levels compared to dipper hypertensives.
  • hs-cTnT serves as a valuable diagnostic biomarker for NDH.
  • hs-cTnT is an independent predictor of nondipping status in hypertension.
Abstract

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