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Ticagrelor for Neuroendovascular Procedures: A Case Series
Kyle Davis1, Christopher Morrison2
11 Internal Medicine, Ochsner Medical Center, New Orleans, LA, USA.
Journal of Pharmacy Practice
|December 28, 2017
Summary
Ticagrelor shows potential safety and efficacy in preventing thromboembolism after neuroendovascular aneurysm repair, warranting further investigation. This study evaluated ticagrelor use in five patients undergoing these procedures.
Area of Science:
- Neuroendovascular surgery
- Cardiovascular research
- Pharmacology
Background:
- Thromboembolism is a frequent complication of neuroendovascular procedures.
- Clopidogrel is considered safe for preventing intracranial stent thrombosis, but ticagrelor's role is unexamined.
- This study investigates ticagrelor's safety and efficacy in neuroendovascular procedures.
Observation:
- Five patients undergoing neuroendovascular aneurysm repair received ticagrelor.
- Three patients had stent-assisted coiling, two had pipeline embolization devices.
- Ticagrelor was used in patients with prior thrombotic events or clopidogrel intolerance.
Findings:
- 60% of patients were successfully treated and discharged on ticagrelor with aspirin.
- Two patients experienced cerebrovascular accidents; one possibly due to medication omission.
- One patient had a retroperitoneal hematoma, but ticagrelor therapy continued.
Implications:
- Ticagrelor may be a safe and effective alternative for patients undergoing neuroendovascular aneurysm repair.
- Further research is needed to confirm these preliminary findings.
- This study contributes to understanding antiplatelet therapy in neuroendovascular interventions.
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