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Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
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IgA Nephropathy after Nivolumab Therapy for Postoperative Recurrence of Lung Squamous Cell Carcinoma

Seiji Kishi1, Masanori Minato1, Atsuro Saijo2

  • 1Department of Nephrology, Graduate School of Biomedical Sciences, Tokushima University, Japan.

Internal Medicine (Tokyo, Japan)
|December 28, 2017
PubMed

Immune checkpoint inhibitors (ICIs) are becoming a common and important cancer therapy. ICIs are associated with a unique category of side effects, termed immune-related adverse events (irAEs). We herein report the case of a 72-year-old man with postoperative recurrence of lung squamous cell carcinoma who was treated with nivolumab and who developed proteinuria and a worsening kidney function. A kidney biopsy revealed IgA nephropathy. After drug withdrawal, the proteinuria improved and the deterioration of the patient's renal function was halted. Although renal irAEs are considered to be rare and glomerulonephritis is not typical presentation, physicians need to pay more attention to renal irAEs and glomerular injury.

Keywords:
IgA nephropathyglomerular injuryimmune-related adverse events (irAEs)nivolumabonconephrology

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