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Updated: Feb 16, 2026

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
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Nuclear receptors in cancer - uncovering new and evolving roles through genomic analysis

Vineet K Dhiman1, Michael J Bolt1, Kevin P White1,2

  • 1Institute for Genomics and Systems Biology, Institute for Molecular Engineering, and Departments of Human Genetics and Medicine, University of Chicago, Chicago, Illinois 60637, USA.

Nature Reviews. Genetics
|December 28, 2017
PubMed

Insights

Nuclear receptors (NRs) are key cancer regulators and therapeutic targets. Advanced sequencing reveals complex NR networks driving cancer, changing our understanding of their oncogenic roles.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Nuclear receptors (NRs) are critical regulators in cancer research, serving as biomarkers and targets for hormone therapy.
  • Tumor cells express diverse NR repertoires, offering complex pathways for disease progression and potential therapeutic interventions.

Purpose of the Study:

  • To explore the role of nuclear receptors (NRs) in cancer development and progression.
  • To investigate the impact of next-generation sequencing on understanding NR transcriptional networks in oncogenesis.

Main Methods:

  • Utilized next-generation sequencing technologies.
  • Analyzed genome-wide insights into NR transcriptional networks.

Main Results:

  • Identified complex interplay within NR transcriptional networks.
  • Demonstrated the contribution of NR networks to cancer development and progression.
  • Revealed altered traditional understanding of NR activities in oncogenesis.

Conclusions:

  • Nuclear receptors play multifaceted roles in cancer, extending beyond traditional hormone-mediated functions.
  • Next-generation sequencing provides crucial insights into NR networks, uncovering new therapeutic avenues.
  • The complex interactions of NRs in cancer necessitate a revised understanding of their oncogenic activities.

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