Related Experiment Video

Updated: Feb 16, 2026

Using Bioluminescent Imaging to Investigate Synergism Between Streptococcus pneumoniae and Influenza A Virus in Infant Mice
10:47

Using Bioluminescent Imaging to Investigate Synergism Between Streptococcus pneumoniae and Influenza A Virus in Infant Mice

Published on: April 14, 2011

17.4K

Influenza B Virus Triggering Macrophage Activation Syndrome in an Infant

K Jayashree1, Suchetha Rao1, Nutan Kamath1

  • 1Department of Pediatrics, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India.

Indian Journal of Critical Care Medicine : Peer-Reviewed, Official Publication of Indian Society of Critical Care Medicine
|December 28, 2017
PubMed

Insights

Macrophage activation syndrome (MAS), a severe condition, was diagnosed in an infant triggered by influenza B. Prompt treatment with immunoglobulin and steroids led to a positive response.

Area of Science:

  • Pediatrics
  • Immunology
  • Hematology

Background:

  • Macrophage activation syndrome (MAS) is a life-threatening hyperinflammatory condition.
  • MAS results from uncontrolled T-lymphocyte and macrophage activation, leading to multi-organ damage.
  • Key clinical features include fever, hepatosplenomegaly, cytopenias, liver dysfunction, and coagulopathy.

Observation:

  • A 10-month-old infant presented with fever, seizures, and enlarged liver and spleen.
  • Initial laboratory findings included bicytopenia, elevated liver enzymes, and low erythrocyte sedimentation rate.
  • Hyperferritinemia and hypertriglyceridemia were noted, strongly suggesting MAS.

Findings:

  • Influenza B virus infection was identified as the trigger for MAS in this infant.
  • The patient exhibited characteristic laboratory markers of MAS, including significant hyperferritinemia.
  • Successful treatment involved intravenous immunoglobulin and corticosteroid therapy.

Implications:

  • This case highlights influenza B as a potential MAS trigger in infants.
  • Early recognition and prompt treatment with immunotherapy are crucial for MAS management.
  • Understanding MAS pathogenesis is vital for developing targeted therapies in pediatric critical care.
Keywords:
Bicytopeniahyperferritinemiahypertriglyceridemiasecondary hemophagocytic lymphohistiocytosisthrombocytopenia

More Related Videos

High-throughput Detection Method for Influenza Virus10:05

High-throughput Detection Method for Influenza Virus

Published on: February 4, 2012

26.8K
Fluorescence-based Neuraminidase Inhibition Assay to Assess the Susceptibility of Influenza Viruses to The Neuraminidase Inhibitor Class of Antivirals09:31

Fluorescence-based Neuraminidase Inhibition Assay to Assess the Susceptibility of Influenza Viruses to The Neuraminidase Inhibitor Class of Antivirals

Published on: April 15, 2017

19.1K

Related Concept Videos

What are Viruses?00:50

What are Viruses?

Overview
128.5K
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
335
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
702
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
1.1K
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
1.2K
Introduction to Virus01:28

Introduction to Virus

Viruses are unique biological entities that blur the boundary between living and non-living systems. Although they lack cellular structure and metabolic processes, they can exhibit characteristics of life when infecting a host. Their defining feature is a nucleic acid core, composed of either DNA or RNA, encapsulated within a protein coat called a capsid. This simple structure allows them to invade host cells and use their machinery for replication efficiently.Viral Structure and...
1.9K