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Pazopanib and Statin-Induced Rhabdomyolysis

Jennifer M Logue1,2, Bahram Kiani1,3, Rhonda L Bitting1,2,4

  • 1Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.

Case Reports in Oncology
|December 28, 2017
PubMed
Abstract

Insights

Pazopanib and rosuvastatin combination therapy can cause rhabdomyolysis, a serious muscle condition. Discontinuing statins may be necessary for advanced cancer patients to prevent severe drug toxicity.

Area of Science:

  • Oncology
  • Pharmacology
  • Nephrology

Background:

  • Pazopanib is a first-line VEGF inhibitor for advanced renal cell carcinoma.
  • Potential drug-drug interactions and toxicities associated with pazopanib may be underrecognized.
Keywords:
Cytochrome p450HyperlipidemiaPazopanibRenal cell carcinomaRhabdomyolysisRosuvastatinStatinVEGF inhibitor

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