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[Relationship between functional constipation and brain-gut-microbiota axis].

Qiyi Chen, Jun Jiang1

  • 1Research Institute of General Surgery, Jinling Hospital, Nanjing 210002, China. jiangjun6987@163.com.

Zhonghua Wei Chang Wai Ke Za Zhi = Chinese Journal of Gastrointestinal Surgery
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Summary
This summary is machine-generated.

Functional constipation involves complex brain-gut-microbiota interactions, not just the colon. Understanding this axis offers new strategies for treating functional constipation and related neuropsychiatric disorders.

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Area of Science:

  • Gastroenterology
  • Neuroscience
  • Microbiology

Background:

  • Functional constipation (FC) has a high prevalence, yet treatment outcomes remain unsatisfactory.
  • Current FC diagnosis and treatment primarily focus on the colon, neglecting systemic interactions.
  • FC is linked to mental and psychological dysfunction, indicating central nervous system involvement.

Purpose of the Study:

  • To explore the complex interactions within the brain-gut-microbiota axis in functional constipation.
  • To investigate the role of intestinal flora in the pathophysiology of FC and associated neuropsychiatric disorders.
  • To propose a broader diagnostic and therapeutic strategy for FC based on brain-gut-microbiota axis modulation.

Main Methods:

  • The study reviews existing literature on the interplay between the central nervous system, enteric nervous system, and gut microbiota in FC.
  • Analysis of the impact of intestinal flora imbalance on neurotransmitter release and the hypothalamic-pituitary-adrenal (HPA) axis.
  • Examination of how central nervous system dysfunction affects colonic dynamics, secretion, and immune function.

Main Results:

  • Patients with FC exhibit significant intestinal flora imbalance and varying degrees of psychological dysfunction.
  • Abnormal brain function in FC patients can lead to disorders in colonic dynamics, secretion, and immune responses.
  • Intestinal flora significantly influences neurotransmitter release and HPA axis activity, impacting central nervous system development and function.

Conclusions:

  • The brain-gut-microbiota axis is a critical factor in the pathogenesis of functional constipation.
  • Dysregulation of the brain-gut-microbiota axis contributes to both FC and neuropsychiatric disorders.
  • Targeting the brain-gut-microbiota axis presents a promising avenue for novel diagnostic and therapeutic approaches for FC.