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Updated: Feb 16, 2026

Procedure for Adaptive Laboratory Evolution of Microorganisms Using a Chemostat

Procedure for Adaptive Laboratory Evolution of Microorganisms Using a Chemostat

Published on: September 20, 2016

Cell ingression: Relevance to limb development and for adaptive evolution.

Clarissa C Pasiliao^1,2, Sevan Hopyan^1,2,3

¹Program in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, Toronto, Ontario, M5G 0A4, Canada.

Genesis (New York, N.Y. : 2000)

|December 28, 2017

Summary

Cell ingression, a key developmental process, involves individual cells constricting and detaching to form structures like limbs. Understanding its cellular and molecular drivers is crucial for developmental biology.

Keywords:

EMT avian cell ingression cell intercalation delamination ectoderm endoderm evolution gastrulation invertebrate lateral plate mesoderm limb bud mammal migration myoblast neural crest signaling transcription

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Area of Science:

Developmental Biology
Cell Biology
Morphogenesis

Background:

Cell ingression is an out-of-plane cell intercalation vital for embryonic development.
It drives key processes like limb bud formation, neural crest cell delamination, and myoblast emigration.

Purpose of the Study:

To review cellular and molecular mechanisms of cell ingression.
To compare ingression across different morphogenetic contexts and model organisms.

Main Methods:

Literature review focusing on cell ingression mechanisms.
Comparative analysis of ingression in various developmental contexts.

Main Results:

Ingressing cells exhibit apical constriction, reduced adhesion, and bleb formation.
These behaviors facilitate movement into subepithelial layers.

Conclusions:

Cell ingression is fundamental to epithelial-to-mesenchymal transition and tissue formation.
Linking signaling pathways to biophysical mechanisms will enhance understanding of ingression.