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Updated: Feb 16, 2026

Generation of Monoclonal Antibodies Against Natural Products
Published on: April 6, 2019
Monoclonal gammopathies: Electronic subspecialty consultation
Nicholas Burwick1,2, Jacob Stein2, David A Garcia1,2
1VA Puget Sound Health Care System, Seattle, WA, USA.
Importance:
Electronic consultation (e-consult) is an important component of care for patients in the Veterans Health Administration who require subspecialty consultation but not urgent face-to-face evaluation. Monoclonal gammopathy of undetermined significance (MGUS) is a common reason for e-consult. While often benign, MGUS requires careful evaluation and persistent surveillance over time.
Objective:
To identify areas to improve MGUS care delivery by e-consult.
Methods:
We performed a retrospective review of our e-consult database and identified a cohort of 152 MGUS patients triaged for e-consult over a 5-year period (2010-2014).
Results:
The median time to completion of an e-consult was 2 days. Ninety-six percent of MGUS e-consults had a hemoglobin >10 g/dL, and 90% had a creatinine <2 mg/dL. While the majority of e-consults were low risk, paraprotein surveillance varied over time and tracked with consult utilization. With a median follow-up of 44 months, there were 6 documented progression events, representing a mean rate of progression of 1% per year.
Conclusions:
E-consult is a helpful mechanism for the evaluation of MGUS, reducing the need for outpatient appointments. However, timely risk stratification and persistent surveillance over time are critical for e-consult to work well.
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